I haven't used baby powder, but I've seen it mentioned here and as far as I know it's OK and would be safe to try. There was one member here some years ago who wondered if it was getting in her pet's urethra, but I don't think she ever knew for sure. The thing I've used to prevent redness under a malewrap is Desitin original diaper cream. It contains zinc oxide but the vet said it would be OK as long as he didn't lick it. I kept an eye on him and he wasn't licking, so it worked really well. I liked the fact that you didn't have to butter him with cream every time you changed the pad, it would last through several changes. In our case, my dog was in his wrap 24/7. If he had been sleeping without it, or if he'd had other time during the day without it, the diaper cream would have posed a problem, because I would have had to be sure to wipe it off before letting him air his skin (because he'd be more likely to lick if he wasn't wearing the wrap). In a case like that, I would prefer a product without zinc, such as plain Vaseline or maybe old fashioned A&D ointment. I tried Vaseline and A&D, but honestly the Desitin worked best at protecting his skin.